Another idea.
This one is simple. Need a female.
A woman has arrived in town after the death of her brother, having been murdered by a rival gang. However, his body has not been recovered and she has set out to find him so he can have a proper funeral. It's left to her to restore her family's reputation as the most powerful organised crime syndicate in the city. I need someone to play that woman (and potentially, later on in the story, some others) who will come across many interesting characters along the way.
OR
Frankie Dupraz has been sent abroad to spearhead the Bernardino crime family's overseas operation. Having just arrived, they obviously start off small, and his boss is counting on him to expand their influence as quickly as he can. However, things don't get off to a good start. He makes plenty of enemies, both from rival gangs and government officials. And then he meets your character. Either she's the bored wife, or beautiful daughter of one of the city's main gangsters. Frankie realises she's nothing but trouble, as she knows how to get what she wants. But will a genuine romance form?